{"id":1815,"date":"2025-10-15T10:17:08","date_gmt":"2025-10-15T10:17:08","guid":{"rendered":"https:\/\/network.rvrising.com\/?p=1815"},"modified":"2025-10-15T10:17:08","modified_gmt":"2025-10-15T10:17:08","slug":"histoindex-to-debut-fibrosight-plus-and-showcase-latest-scientific-findings-at-aasld-the-liver-meeting-2025","status":"publish","type":"post","link":"https:\/\/www.rvrising.com\/news\/business\/histoindex-to-debut-fibrosight-plus-and-showcase-latest-scientific-findings-at-aasld-the-liver-meeting-2025\/","title":{"rendered":"HistoIndex to debut FibroSIGHT\u2122 Plus and showcase latest scientific findings at AASLD The Liver Meeting\u00ae 2025"},"content":{"rendered":"<p><span class=\"legendSpanClass\">SINGAPORE<\/span>, <span class=\"legendSpanClass\">Oct. 14, 2025<\/span> \/PRNewswire\/ &#8212; HistoIndex, a pioneering leader in digital pathology solutions for chronic liver disease, is returning to The Liver Meeting\u00ae (TLM) 2025, hosted by the American Association for the Study of Liver Diseases (AASLD). The conference, which brings together leading scientists, clinicians, and industry experts in hepatology, will be held from November 7th to 11th, in Washington D.C.<\/p>\n<div>\n<p>This year marks a significant milestone for HistoIndex as the company expands its services from clinical trials and research, to clinical diagnostics for Metabolic Dysfunction\u2013Associated Steatohepatitis (MASH). Highlight of this new phase is the launch of <b>FibroSIGHT\u2122 Plus<\/b>, a Laboratory Developed Test (LDT), provided for clinical use from a CLIA-accredited laboratory in the US.\u00a0 FibroSIGHT\u2122 Plus will be used to deliver enhanced diagnostics with quantitative liver fibrosis assessment for better patient management in the rapidly evolving field of MASH therapeutics. &#8220;We&#8217;re excited to bring the same standardization and fine-grained resolution of fibrosis measurements that enabled many therapeutic insights in MASH clinical trials, into everyday clinical care &#8211; enabling more precise liver diagnostics and better outcomes for MASH patients.&#8221; said Dr. Yukti Choudhury, PhD &#8211; Chief Development Officer at HistoIndex.<\/p>\n<p>Furthermore, HistoIndex maintains a strong scientific presence at TLM 2025, showcasing <b>1 oral and 10 poster presentations (including 2 posters of distinction and 1 late-breaking poster) <\/b>that underscore the growing impact of its digital pathology technology platform across diverse liver diseases and therapeutic contexts.<\/p>\n<p><b> <u>HistoIndex&#8217;s scientific highlights for TLM 2025<\/u> <\/b><\/p>\n<ul type=\"disc\">\n<li><b>Two Posters of Distinction<\/b> showcasing improved fibrosis detection in advanced MASH fibrosis and cirrhosis from two separate drug trials. These findings demonstrate the ability of HistoIndex&#8217;s platform to assess treatment effect in the greatest unmet need of MASH, namely advanced fibrosis and cirrhosis.<\/li>\n<li><b>An oral presentation <\/b>with a focus on one of the first applications of Artificial Intelligence (AI)-based biopsy analysis in an alpha-1 antitrypsin deficiency (AATD) drug trial, expanding the utility of our qFibrosis\u00ae technology beyond MASH.<\/li>\n<li><b>A late-breaking poster<\/b> discussing the use of digital pathology and AI-based analysis in assessing quantitatively the reduction of fibrosis and septa area in participants with compensated cirrhosis due to MASH from the SYMMETRY Phase 2b trial.<\/li>\n<li><b>New data <\/b>will also be presented on the development of AI-based tools for inflammation assessment, microvasculature quantification in MASH portal hypertension, and characterization of fibrosis distribution in preclinical MASH-associated liver cancer models.<\/li>\n<\/ul>\n<p>Highlighting the significance of this year&#8217;s presentations, Dr. Dean Tai, PhD, Chief Scientific Officer at HistoIndex, commented: &#8220;Our work at AASLD 2025 shows how our technology advances AI-based digital pathology assessments in liver disease and beyond. From detecting nuanced treatment effects in advanced MASH fibrosis and cirrhosis to continuing to expand into AATD, inflammation, vascular assessment, and MASH-HCC models, these studies highlight the wide clinical applications of our technology.&#8221;<\/p>\n<p><b> <u>HistoIndex Oral and Poster Presentations<\/u> <\/b><\/p>\n<p><b>Oral Presentation | Sunday, November 9<sup>th<\/sup> | 9:15AM to 9:30AM<\/b><\/p>\n<p><b>Poster Session I | Friday, November 7<sup>th<\/sup> | 8:00AM \u2013 5:00PM<\/b><\/p>\n<ul type=\"disc\">\n<li><b>Title: <\/b>Increased hepatic microarteries and collagen deposition in acinar zone 1 are associated with clinically significant portal hypertension caused by metabolic associated steatotic liver disease<b>Presenter:<\/b> Zhengxin Li\n<p><b>Publication number:<\/b> 1460<\/li>\n<li><b>Title: <\/b>Zonal dynamics of fibrosis progression and regression in a murine MASLD-HCC model using AI-Based collagen and steatosis analysis<b>Presenter:<\/b>\u00a0Yuyun Song\n<p><b>Publication number:<\/b> 1093<\/li>\n<\/ul>\n<p><b>Poster Session II | Saturday, November 8<sup>th<\/sup> | 8:00AM \u2013 5:00PM<\/b><\/p>\n<ul type=\"disc\">\n<li><b>Title<\/b>: Zone-specific fibrosis reductions induced by pegozafermin over 24 weeks are similar in non-cirrhotic (F2\/F3) and cirrhotic (F4) MASH <b>(Poster of Distinction)<\/b><b>Presenter:\u00a0<\/b>Quentin Anstee\n<p><b>Publication Number: <\/b>2020<\/li>\n<li><b>Title<\/b>: Impact of PNPLA3 p.I148M variant on qFibrosis-based liver fibrosis features in MASLD biopsies in the Milan Biobank cohort<b>Presenter: <\/b>Luca Valenti\n<p><b>Publication Number:<\/b>\u00a0 2054<\/li>\n<li><b>Title:<\/b> Second harmonic generated imaging with qFibrosis provides quantitative information on fibrosis severity and predicts the future course of fibrosis in metabolic dysfunction associated steatotic liver disease (MASLD)<b>Presenter:\u00a0<\/b>David Kleiner\n<p><b>Publication Number:<\/b>\u00a02086<\/li>\n<li><b>Title: <\/b>Development and Validation of qInflammation: An AI-Driven Digital Pathology Algorithm for Differentiating Portal and Lobular Inflammation in Metabolic-Associated Steatohepatitis<b>Presenter: <\/b>Yayun Ren\n<p><b>Publication number:<\/b>\u00a02027<\/li>\n<li><b>Title:<\/b> AI-assisted digital pathology unveils patient heterogeneity in the antifibrotic response following bariatric surgery<b>Presenter:<\/b>\u00a0Vlad Ratziu\n<p><b>Publication number:<\/b> 2131<\/li>\n<\/ul>\n<p><b>Late Breaking Posters | Saturday, November 8<sup>th<\/sup> | 8:00AM <\/b> <b>\u2013 5:00PM<\/b><\/p>\n<p><b>Poster Session IV | <\/b> <b>Monday, November 10<sup>th<\/sup><\/b> <b>| 8:00AM \u2013 5:00PM<\/b><\/p>\n<p><b>MASLD\/MASH \u2013 Therapeutics Session: New Agents and Approved\/Available Agents (&#8220;4001-4103&#8221;)<\/b><\/p>\n<ul type=\"disc\">\n<li><b>Title:<\/b> Denifanstat elicited a significant \u22652-stage improvement in fibrosis in F3 MASH patients, and improved liver fibrosis and biomarkers in qFibrosis stage 4 MASH patients: secondary analysis of phase 2b FASCINATE-2 study <b>(Poster of Distinction)<\/b><b>Presenter:<\/b>\u00a0Rohit Loomba<\/li>\n<li><b>Title: <\/b>Combination therapy in Metabolic Dysfunction \u2013 associated Steatohepatitis: GLP-1R Agonist with others<b>Presenter:\u00a0<\/b>Li Hui<\/li>\n<\/ul>\n<p><b> <u>HistoIndex Breakfast Meeting<\/u> <\/b><\/p>\n<p>In addition to the scientific sessions, HistoIndex will be hosting its signature breakfast meeting event on November 8th (Saturday), spotlighting its multi-institutional collaboration with the National Institutes of Health (NIH) and Virginia Commonwealth University (VCU), where stain-free Second Harmonic Generation (SHG) and AI analytics are being applied to the NASH-CRN cohort to enable identification of fibrosis trajectories. To secure a slot at the HistoIndex Breakfast Meeting, register <u><a href=\"https:\/\/forms.gle\/thD68JPZKJDJ5wTV6\" target=\"_blank\" rel=\"nofollow noopener\">here<\/a><\/u>.<\/p>\n<p><b> <u>HistoIndex Dinner Reception (Clinical Diagnostics Event)<\/u> <\/b><\/p>\n<p>To mark its expansion into clinical diagnostics and the launch of its LDT, FibroSIGHT\u2122 Plus, HistoIndex will also host a dedicated dinner event highlighting its services for MASH routine clinical care.<\/p>\n<p>The program, titled <b>&#8220;Latest Advancements in MASH Diagnostics: AI-driven Fibrosis Assessment&#8221;<\/b> will introduce FibroSIGHT\u2122 Plus \u2013 a clinical testing solution offering AI-based quantitative analysis for fibrosis assessment, that has been developed to address unmet clinical needs in the appropriate selection of MASH patients for treatment and for treatment response detection.<\/p>\n<p>Special guest speaker Dr.\u00a0Naim Alkhouri, MD, FAASLD &#8211; Chief Academic Officer at Summit Clinical Research and the Director of the Steatotic Liver Disease Program at the Clinical Research Institute of Ohio &#8211; will be presenting new data from a study that compares quantitative AI-based analysis to pathologists&#8217; assessment of fibrosis. These new findings will be placed in the context of limitations of NITs and standard pathology in identifying target populations for MASH treatment and its potential impact on patient management.<\/p>\n<p>The event is tailored for hepatologists and gastroenterologists. Clinicians are invited to register early <u><a href=\"https:\/\/forms.gle\/t7SZTo9NJNbq3Xw49\" target=\"_blank\" rel=\"nofollow noopener\"><span id=\"spanHghltfcc4\">here<\/span><\/a><\/u>, as seats for this event are limited.<\/p>\n<p><b> <u>Visit HistoIndex at Booth #645 <\/u> <\/b><\/p>\n<p>HistoIndex will be exhibiting at TLM 2025 at <b>Booth #645, <\/b>unveiling a vibrant and expanded showcase that features the launch of <b>FibroSIGHT\u2122 Plus<\/b>. Attendees are encouraged to visit the booth and explore how HistoIndex&#8217;s technology is redefining liver fibrosis assessment with AI-powered precision.<\/p>\n<p>The Company&#8217;s team of experts will be available to provide detailed information, address inquiries, and explore potential collaborations.<\/p>\n<p>For more information about HistoIndex&#8217;s participation in TLM 2025, please visit <a href=\"https:\/\/www.histoindex.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.histoindex.com<\/a>.<\/p>\n<p><b>About HistoIndex<\/b><\/p>\n<p>Founded in 2010, HistoIndex pioneers in stain-free, fully automated imaging solutions for visualizing and quantifying fibrosis in biological tissues. By combining cutting-edge biophotonic technology with AI-based analysis, HistoIndex provides innovative tools to improve the assessment of fibrosis changes and drug efficacy. The Company&#8217;s breakthrough digital pathology solutions are accelerating research, expediting pharmaceutical drug development, and transforming medical standards.<\/p>\n<p>SOURCE Histoindex Pte. Ltd.<img decoding=\"async\" style=\"border: 0px; width: 1px; height: 1px;\" src=\"https:\/\/rt.prnewswire.com\/rt.gif?NewsItemId=CN97471&amp;Transmission_Id=202510142300PR_NEWS_USPR_____CN97471&amp;DateId=20251014\" alt=\"\" \/><\/p>\n<\/div>\n<p><b>This release is auto-published via PR Newswire; our journal is not responsible for the content.<\/b><\/p>\n<p><a href=\"https:\/\/www.prnewswire.com\/news-releases\/histoindex-to-debut-fibrosight-plus-and-showcase-latest-scientific-findings-at-aasld-the-liver-meeting-2025-302584158.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>SINGAPORE, Oct. 14, 2025 \/PRNewswire\/ &#8212; HistoIndex, a pioneering leader in digital pathology solutions for chronic liver disease,<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,92],"tags":[532],"class_list":["post-1815","post","type-post","status-publish","format-standard","hentry","category-business","category-pr-newswire","tag-histoindex-pte-ltd"],"_links":{"self":[{"href":"https:\/\/www.rvrising.com\/news\/wp-json\/wp\/v2\/posts\/1815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rvrising.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rvrising.com\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rvrising.com\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rvrising.com\/news\/wp-json\/wp\/v2\/comments?post=1815"}],"version-history":[{"count":1,"href":"https:\/\/www.rvrising.com\/news\/wp-json\/wp\/v2\/posts\/1815\/revisions"}],"predecessor-version":[{"id":1846,"href":"https:\/\/www.rvrising.com\/news\/wp-json\/wp\/v2\/posts\/1815\/revisions\/1846"}],"wp:attachment":[{"href":"https:\/\/www.rvrising.com\/news\/wp-json\/wp\/v2\/media?parent=1815"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rvrising.com\/news\/wp-json\/wp\/v2\/categories?post=1815"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rvrising.com\/news\/wp-json\/wp\/v2\/tags?post=1815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}